… oocyte and early embryo, PADI6 is crucial for early embryonic development and female fertility
… cell lines, potentially affecting cellular cytoskeletal dynamics and cell migration. Together …

… KO mice are infertile, while males are fertile [93]. A similar … complex in the oocyte cytoplasm,
which is required for early … In non-reproductive models, the citrullination of cytoskeletal …

… mutations in the peptidylarginine deiminase type VI (PADI6) … in mammalian oocytes and
early embryos, essential for … cofilin controlled the formation of the actin cytoskeleton which …

… oocytes and early embryos based on our in-house database; 6) genes previously reported
to affect female fertility … PADI6 is a member of the peptidylarginine deiminase (PADI) family, a …

… Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and
female fertility… cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007;273(…

… were proposed to be oocyte-specific in… oocyte-specific proteins that are essential for the
formation of cytoplasmic lattices. These proteins were PADI6 (peptidylarginine deiminase 6) and …

… PAD6 is thought to be the only catalytically inactive PAD and is expressed mainly in oocytes…
to be involved in oocyte cytoskeletal sheet formation and female fertility. PAD1 and PAD3 …

… Therefore, the latest insights reveal how PAD activity affects cytoskeletal organization and
… Citrullination should no longer be considered as a rare PTM, but as an important regulatory …

… in female fertility is largely ascribable to the decrease in oocyte … It regulates F-actin cytoskeleton
via Cofilin in mouse zygotes, … (OOEP/FLOPED), peptidyl arginine deiminase 6 (PADI6), …

… a 32-year-old female who had been diagnosed with primary fertility for 12 years and … oocytes
and early embryos. It encodes peptidyl arginine deiminase, type VI, and plays an important …